Prevalence of Thyroglobulin Antibody (TgAb) Positivity in Patients Post Treatment for Differentiated Thyroid Carcinoma and Verification of Serum Thyroglobulin Measurements by Thyroglobulin Recovery Test and TgAb assay

Introduction: Thyroglobulin (Tg) measurement is important for detection of disease recurrence in patients with differentiated thyroid carcinoma (DTC). However, its affected by Tg autoantibodies (TgAb). Calculation recovery may complement quantitative TgAb interference. This study aimed to determine the prevalence positivity samples received from post-thyroidectomy DTC Hospital Pulau Pinang (HPP). Additionally, we assessed use II Confirmatory Test (Roche Diagnostics) assay calculate detecting Method: Samples measurements were tested Test. The levels [categorised as biochemically detectable (≥1.0 μg/l) vs undetectable (<1.0 μg/l)], and correct (70%-130%) compromised (<70% >130%) recovery] interpreted diagnostic radioiodine uptake (RAI) results. Results: In this study, 58/73 (79.5%) had Tg. A was observed three (4.1%) samples. Only 51 out 73 subjects an RAI performed, which 27 (52.9%) increased (radiological evidence persistent/recurrent disease). Of those uptake, 17 (63%) Tg, none recovery. Conclusion: presence prevents reliable calculation did not provide additional complementary value interference measurements.